SRS - Piscirickettsiosis challenge model
Piscirickettsia salmonis is the aetiological agent of Salmon Rickettsial Septicemia (SRS) or Piscirickettsiosis. The disease causes high mortality and significant economic losses to the salmon industry.
To evalueren de werkzaamheid of prophylactische maatregelen tegen Piscirickettsiose, experimentele infectieproeven zijn indispensable. VESO Vikan offers experimental i.p. and cohabitation challenge models in fresh water and sea water.
Pre-smolts to be included in an i.p. of cohabitant challenge study are photoperiod-manipulated to smoltify before adaptation to sea water. Fish will be acclimatized to 15 ° C before challenge with an EM90-like strain of Chilean origin. If the fish are included in a vaccination trial, vaccination will be performed during the smoltification period. The test fish are challenged after transfer to sea water, either by i.p. injection of bacteria or by addition of i.p. injected shedders to the tank containing the test fish. After challenge the fish are kept under close observation and mortalities registered.
Figure: Mortality after i.p. challenge (shedder) and cohabitation challenge (saline injected control).